Tumor Suppressor Gene-Inducible Cell Lines

In a noncancerous mammalian cell, the growth-promoting effects of proto-oncogenes are counterbalanced by the growth-constraining effects of tumor suppressor genes (TSGs). The net result is a masterfully orchestrated display of cell proliferation in the absence of tumorigenesis. The significance of this relationship is most evident in tumor cells, where the accumulation of genetic mutations has upset this critical balance of power.