Synthesis of 2-O-Alkyloligoribonucleotides

2′-O -Alkyloligoribonucleotides possess properties that render them ideally suited for studying RNA processing and for the affinity chromatography of RNA-protein complexes. Particularly useful compounds are those in which alkyl is methyl (1 –7 ), ethyl (8 ), allyl (9 ), or butyl (10 ), with most studies being carried out with the methyl and allyl analogs.