Oligonucleotide Analogs Containing Dephospho-Internucleoside Linkages
Nonionic oligonucleotide analogs have attracted much interest in recent years as
Nonionic oligonucleotide analogs have attracted much interest in recent years as potential candidates for oligonucleotide-based therapeutics. Compared to their natural parent molecules, they are expected to have the advantage of:
| 1. | Being stable against degrading nucleases, |
| 2. | Showing enhanced cellular uptake, and |
| 3. | Having the ability to form more stable complexes with complementary sequences owing to reduced charge repulsion. |
相关文章
