Chiral Separations by Simulated Moving Bed Method Using Polysaccharide-Based Chiral Stationary Phase

Generally, in using chromatography as an industrial-scale production process, batch separation is not adequate from the standpoint of productivity and mobile phase consumption; thus, a continuous separation is preferred. The simulated moving bed (SMB) method is one of the best popular practices of continuous chromatographic separation. In this chapter, I would like to introduce actual practices of chiral SMB using polysaccharide-derived chiral stationary phases (CSPs), together with some laboratory-scale separation data.