Nitric Oxide Synthase

Nitric oxide (NO) is an important bio-regulatory molecule in the nervous, immune and cardiovascular systems. The physiological involvement of NO in neuronal transmission, control of vascular tone, and immune response-induced cytostasis as well as the deleterious effects associated with altered levels of NO synthesis (1 ,2 ) culminated in the selection of the free-radical gas as “1992 Molecule of the Year” (3 ).