Login
欢迎浏览恩派尔生物资料网
我要投稿 请登录 免费注册 安全退出

您现在的位置是: 首页 > 实验方法 > 细胞技术

细胞技术

MAPK signaling pathway - Homo sapiens (human)

2025-02-26 细胞技术 加入收藏
相关专题 MAPK信号通路专题MAPK signaling pathway - Homo sapiens (human):The mitogen-activat

相关专题 MAPK信号通路专题

MAPK signaling pathway - Homo sapiens (human):The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various Cell ular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.


文章底部广告位

文章评论

加载中~