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细胞技术

Monitoring Oncogenic B-RAF-Induced Senescence in Melanocytes

2025-02-28 细胞技术 加入收藏
The B-RAF kinase is a downstream effector of the RAS family of proto-oncogenes a

The B-RAF kinase is a downstream effector of the RAS family of proto-oncogenes and is constitutively activated in the majority of human melanomas. The common oncogenic B-RAFV600E mutant cooperates with additional genetic lesions to transform immortal murine and human cells. In primary cells, however, B-RAFV600E triggers a rapid cell cycle arrest that is phenotypically indistinguishable from cellular senescence. Here we describe the analyses of B-RAF-induced senescence in primary human melanocytes using recombinant lentiviruses.

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