Synthesis, Characterization, and Evaluation of Radiometal-Containing Peptide Nucleic Acids
Peptide nucleic acids (PNAs) have very attractive properties for applications in
Peptide nucleic acids (PNAs) have very attractive properties for applications in nuclear medicine. Because PNAs have high selectivity for DNA/RNA recognition, resistance to nuclease/protease degradation, and high thermal and radiolytic stabilities, PNA bioconjugates could transform the areas of diagnostic and therapeutic nuclear medicine. In this book chapter, we report on the current developments towards the preparation of radiometal-containing PNA constructs and summarize the protocols for labeling these probes with 99mTc, 111In, 64Cu, 90Y, and 177Lu.
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Use of Peptide Nucleic Acids (PNAs) for Genotyping by Solution and Surface Methods
Peptide nucleic acids (PNAs) are synthetic oligonucleotide a...
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Peptide Microarrays on Coated Silicon Slides for Highly Sensitive Antibody Detection
Peptides, with their well-established chemistry and fully au...
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